From Destinypedia, the Destiny wiki
Splicers are a secret collective in Fallen Houses, charged with the augmentation of other House members with cybernetics, body hacking, bio-engineering, unraveling technology, and enhancing the Eliksni species' evolution.  All Fallen Houses possess Splicers, filled with their best scientists and engineers.
The most notable of these specialized groups are the Devil Splicers, a radical sect within the House of Devils devoted to the Golden Age technology, SIVA. They are responsible for the creation of the Plaguelands within the Cosmodrome.
List of appearances