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"A mysterious rune. Its aura matches those of the planetshifting Hive who periodically appear on the Dreadnaught.."
— Item description

An Agonarch Rune is received as you kill Hive Majors on the Dreadnaught. It is useless unless you kill the Taken that rotate daily around the Hull Breach and the Mausoleum. Once done you will receive a Charged Agonarch Rune.